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The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Alonso, J. L. Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity. Phytother. SAIZEN vial safely in accordance with your local requirements.

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Lab tests, including calcium, phosphorus, magnesium, and alkaline phosphate levels, may be performed while you use calcitriol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Readily crosses the placenta. Calcitriol is to be used only by the patient for whom it is prescribed. Do not share it with other people.

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If you think your may have hyperthyroidism, please see your veterinarian immediately. And remember, please do not give any medication to your pet without talking to your veterinarian first. What Is Hyperthyroidism? Similar to patients with hyperthyroidism, those with hypothyroidism often present with depression and anxiety. The usual clinical features include apathy, psychomotor retardation, depression, and poor memory. However, when hypothyroidism develops rapidly, the psychiatric features are usually delirium and psychosis, which has also been termed myxedema madness. Physical signs and symptoms, including cold intolerance, weight gain, thin and dry hair, facial puffiness, constipation, menorrhagia, muscle cramps, and slowed and decreased deep tendon reflexes, suggest this diagnosis.

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Unless hypothyroidism stems from a primary pituitary disorder, it is usually caused by a lack of T4, which results in an elevated TSH level. Ask your doctor to write a letter describing the radiation isotope used, the date and time of treatment, the dose, and its biological half-life how long it takes for half of the radioactive iodine to be eliminated from the body. The letter should include your doctor's 24-hour telephone numbers so that authorities can call your doctor if they need to verify the information in the letter. See Hepatotoxicity under Cautions. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.



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Surgical removal of the thyroid gland. Hyperthyroidism is usually caused by a benign tumorcalled a thyroid adenoma that involves one or, more often, both thyroid glands. Fortunately, most hyperthyroid cats have benign, well-encapsulated tumors that are easily removed. Surgery usually results in a palliation and not a cure, but can be challenging in these older patients whose disease may have affected their hearts and other organs. Although surgery may seem costly, it often ends up being less expensive than years of oral medication and regular bloodwork rechecks. T4 numbers at all. All my thyroid med's have done for me so far is make me look, walk and feel like I'm pregnant. I'm all swelled up from head to toe. I've been on this stuff since mid-May and all it's getting me is tired and fat. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. What factors determine bone strength? If your doctor has directed you to use this product, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this product not have serious side effects. Vonk, R. J. Dumping syndrome in children. Diagnosis and effect of glucomannan on glucose tolerance and absorption. Acta Paediatr. If a child is using this medicine, tell your doctor if the child has any changes in weight. Methimazole doses are based on weight in children, and any changes may affect your child's dose. If you miss a dose of methimazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.



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If used during pregnancy or if patient becomes pregnant while receiving the drug, apprise of potential hazard to the fetus; inform patient of risks of methimazole-associated fetal malformations and risks of propylthiouracil-associated hepatotoxicity when considering antithyroid drug use during pregnancy. The diluent contained in click. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Not known if risk of methimazole-induced aplasia cutis or embryopathy outweighs risk of propylthiouracil-induced hepatotoxicity. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Using methimazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Manufacturer recommends administering total daily dosage usually in 3 equally divided doses at approximately 8-hour intervals. 101 Alternatively, some clinicians state that drug may be administered as a single daily dose. Takata K, Kubota S, Fukata S et al. Methimazole-induced agranulocytosis in patients with Graves' disease is more frequent with an initial dose of 30 mg daily than with 15 mg daily. Thyroid. What brand names are available for methimazole? Because several common diseases of older cats-, inflammatory bowel disease, intestinal and chronic -share some of the clinical signs of hyperthyroidism, a battery of tests is in order. A CBC, chemistry panel and urinalysis alone will not diagnose hyperthyroidism, but they can certainly rule out diabetes and kidney failure. Hyperthyroid cats may have normal findings on the CBC and urinalysis, but the chemistry panel often shows elevation of several liver enzymes.



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Because these are geriatric cats, concurrent illness is fairly common, and diagnosis of hyperthyroidism in these cats can be tricky. Marks, V. The effect of soluble- and insoluble-fibre supplementation on post-prandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects. Liu, S. Y. Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial. De Villiers, L. S. The effects of the dietary fibre component konjac-glucomannan on serum cholesterol levels of hypercholesterolemic subjects. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. At first, 15 to 60 milligrams mg per day, divided in 3 equal doses and given about every 8 hours. The maintenance dose is 5 to 15 mg per day. Cooper DS, Rivkees SA. Putting propylthiouracil in perspective. J Clin Endocrinol Metab. SAIZEN is also available in the click. This list is not complete and other drugs may interact with methimazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Serum TSH not a reliable parameter to monitor early in therapy because it may remain suppressed for several months after initiation of therapy despite normalization of free T 4 concentrations. 118 122 123 124 A suppressed TSH concentration during this period does not indicate a need for dosage increase. 123 However, once hyperthyroidism resolves, decrease maintenance dosage if serum TSH is elevated. 101 123 Monitoring serum T 3 concentrations may sometimes be useful for dosage adjustment; if total or free T 3 concentrations remain elevated despite low, normal, or reduced free T 4 concentrations, may need to increase antithyroid dosage. Methimazole may also be used for other purposes not listed in this medication guide. For most people, one dose of radioactive iodine treatment will cure hyperthyroidism. Usually, hormone levels return to normal in 8 to 12 weeks. In rare cases, the person needs a second or third dose of radioactive iodine. Our Tapazole Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Consult your doctor before -feeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.



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Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. If your thyroid nodule gets bigger, your doctor may recommend another to see whether the nodule has become cancerous. If your nodule has become cancerous or appears to be cancerous, your doctor will probably recommend surgery thyroidectomy to remove some or all of your thyroid gland. You may also need radioactive iodine. Liver problems may occur while you are using methimazole. This is not a very common problem. Check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin. The Thyroid and the Mind and Emotions thyroid. Ages Are Prone to Hyperthyroidism? Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses. You have or another kind of hyperthyroidism that is often temporary. P450 CYP450 mediated antipyrine clearance in man. May be used for management of thyrotoxic crisis, 118 b although not considered antithyroid agent of first choice.



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Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. This should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: disease. Instructions for Use provided with the administration device. WebMD. This is what was posted. Stagnaro-Green A, Abalovich M, Alexander E et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. If your doctor prescribes these medicines together, you may need to have your bleeding times checked more often. If you have any signs of bleeding, such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools, contact your doctor right away. Do not keep outdated medicine or medicine no longer needed. See Hematologic Effects under Cautions. Do not receive a "live" vaccine while you are being treated with methimazole, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Surgery is usually only necessary if your thyroid nodule is so large that it causes problems with breathing or swallowing or if your nodule is cancerous. After a cancerous nodule is surgically removed, you may get a treatment of radioactive iodine to destroy more tissue in that area. If you need to have your entire gland removed, you will need to take thyroid hormone medicine for the rest of your life. Schedule regular checkups with your doctor. Even noncancerous nodules need to be looked at by your doctor on a regular basis. Interactions. If you take any medicines regularly, you must talk to your doctor before you start using L-carnitine supplements. They could interact with many drugs such as for infections. Eunice Kennedy Shriver National Institute of Child Health and Human Development.



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Some of the side effects that can occur with methimazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. An underactive thyroid can lead to progressive loss of interest and initiative, slowing of mental processes, poor memory for recent events, fading of the personality's colour and vivacity, general intellectual deterioration, depression with a paranoid flavour, and eventually, if not checked, to dementia and permanent harmful effects on the brain. In instances of each condition, some persons have been wrongly diagnosed, hospitalized for months, and treated unsuccessfully for psychosis. Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan amorphophalus konjac. J Hepatol. Unusually low or unusually high thyroid levels. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Studies have suggested that the risk of agranulocytosis is greater in older patients and that they have a higher rate of death. Rivkees SA, Mattison DR. Propylthiouracil PTU hepatotoxicity in children and recommendations for discontinuation of use. Int J Pediatr Endocrinol. 2009. Article ID 132041. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Sinhaseni, P. Increase in tumour necrosis factor-alpha and a change in the lactate dehydrogenase isoenzyme pattern in plasma of workers exposed to aflatoxin-contaminated feeds. Arh. Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol. These symptoms might not start until your platelet count is very low. If you notice any of them, call your doctor. Gastrointestinal GI side effects have included GI upset 5% nausea, vomiting, epigastric distress, and taste disturbances. Pancreatitis has been reported very rarely.



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In the vast majority of cases, a definitive diagnosis of hyperthyroidism is based on a simple blood test that shows elevated T 4 levels in the bloodstream. Unfortunately, between 2 percent and 10 percent of cats with hyperthyroidism will have normal T 4 levels. One possible explanation for this is that in mild cases, T 4 levels can fluctuate in and out of the normal range. Ask your health care provider any questions you may have about how to use calcitriol. Doctors are also using it more frequently to treat children older than 5 years. Radioactive iodine treatment can make your neck swell up or hurt. Serious and sometimes fatal infections may occur during treatment with methimazole. You may also take that can make you feel better and help your thyroid return to normal before you are given radioactive iodine. What other drugs will affect methimazole? Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Florholmen, J. Experiences with three different fiber supplements in weight reduction. Med Sci Monit. Therapy with methimazole returns the hyperthyroid patient to a normal metabolic state prior to thyroidectomy and controls the thyrotoxic crisis that may accompany thyroidectomy. Most people-depending on their ages, how much thyroid hormone their bodies make, and other health conditions they have-are treated first with radioactive iodine. Using methimazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Methimazole can increase your risk of bleeding. If you need to have surgery, tell the surgeon ahead of time that you are using this medication.



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Do not take other medicines unless they have been discussed with your doctor. Orbital decompression surgery involves removing the bone between your and socket. It can help by making extra room for your eyes so that they go back to their normal position. It can help improve your vision. There are risks to the surgery, including double vision. SAIZEN solution from the click. If any of these effects persist or worsen, tell your doctor or promptly. Metabolic side effects including rare reports of hypoglycemia have been reported. This information should not be used to decide whether or not to take calcitriol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about calcitriol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to calcitriol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using calcitriol. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects.



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Seigel SC, Hodak SP. Thyrotoxicosis. In instances of each condition, some persons have been wrongly diagnosed, hospitalized for months, and treated unsuccessfully for psychosis. Antineutrophil cytoplasmic antibody ANCA-positive vasculitis with acute renal failure, arthritis, skin ulcerations, and a vasculitic rash reported rarely. 122 If ANCA-positive vasculitis occurs, discontinue methimazole. Switch patients receiving methimazole to propylthiouracil if pregnancy is confirmed in first trimester. Do not stop taking any medications without consulting your healthcare provider. SAIZEN vial from the click. Your nodule is so big that it makes it hard for you to breathe or swallow. Drugs for thyroid disorders. Treat Guidel Med Lett. Walter MA, Briel M, Christ-Crain M et al. Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials. BMJ. This should not be used if you have certain medical conditions. Therefore, some clinicians suggest to treat adults with overt toxic adenoma or toxic multinodular goiter with either radioactive iodine therapy or thyroidectomy, and to avoid long-term methimazole therapy. Can adding certain foods to one's diet help to prevent osteoporosis?



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Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. This medication may rarely cause very serious blood disorders such as a low number of red cells, white cells, and platelets especially during the first few months of treatment. Mild hyperthyroidism: 5 mg orally every 8 hours.

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Inhibits the synthesis of thyroid hormones 101 by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin; b also inhibits the coupling of these iodotyrosyl residues to form iodothyronine. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.

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The FDA approved methimazole in March 1999. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Renal side effects have rarely included nephritis. Do I need a prescription for methimazole?

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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. You can bleed outside or inside your body. Sometimes it can be heavy or hard to stop. Some people get nosebleeds or bleeding gums.

It is very important that your doctor check your progress at regular visits to make sure that the medicine is working properly. Blood tests may be needed to check for unwanted effects. Discontinue methimazole at time of procedure. The onset of aplastic anemia pancytopenia or agranulocytosis may occur in hours to days. Most cases of agranulocytosis occur within the first 90 days of treatment, but this complication can occur even a year or more after starting therapy. In the case of an overabundance of thyroxin flooding through the system and supercharging every cell to an unhealthy degree, the result can be another autoimmune disorder called Grave's disease. Although late in the progression you may lose weight, Vliet says, at first you will be gaining just as with hypothyroidism.

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